منابع مشابه
Microbial Transformation of Antibiotics: Phosphorylation
Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor MUller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with alkaline phosphatase generated a biologically active material identified as clindamycin. Fermentation broths containing inactivated clindamycin yielded clindamycin 3-phosphate, the structu...
متن کاملMICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
متن کاملMicrobial transformation of antibiotics II. Additional transformation products of maridomycin III.
Streptomyces sp. strain No. K-245 was found to transform maridomycin III into four derivatives (A1, A2, A3 and A4) in addition to the transformation products reported previously. Isolation of the main product A1 was carried out by column chromatography on silica gel developed with CHCl3-MeOH (19:1). From the partial investigation of the structure of A1, it proved to have a C-18-aldehyde group a...
متن کاملMicrobial transformations of antibiotics.
In spite of their unusual molecular structures and seemingly high degree of biological recalcitrance, many antibiotics have been shown to be susceptible to microbial attack. Among the types of changes brought about by microbial systems are: (i) acylation; (ii) phosphorylation; (iii) adenylylation and ribonucleotide formation; (iv) hydrolysis; (v) oxidation; (vi) suiph oxidation; (vii) reduction...
متن کاملMicrobial Degradation of Sulfonamide Antibiotics
Certain microbes can transform antibiotics in the environment. However, little is known about the identity of these microbes and their antibiotic biotransformation processes. The objectives of this study were to (1) isolate bacterial strains capable of transforming antibiotics, (2) determine the biotransformation kinetics of antibiotics, (3) characterize the effects of background carbons on the...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1972
ISSN: 0002-1369
DOI: 10.1080/00021369.1972.10860273